Antioxidant and Anti-inflammatory Activities Mediate the Radioprotective Effect of Trianthema portulacastrum L. Extracts

Background: Ionizing radiation (IR) generates reactive oxygen species (ROS), which leads to oxidative stress that often inflammatory responses in organisms. Objective: Trianthema portulacastrum L., a plant commonly growing India, is rich antioxidant phytochemicals. This responsible for scavenging free radicals and may provide radioprotective anti-inflammatory effects response ionizing radiation. Methods: The effect of T. extracts was studied hepatic cells, are susceptible radiation-induced damage macrophages, the primary cells body. Results: stem showed efficient radical activity hepatocytes decreased lipid peroxidation cell mitochondrial membranes. Treatment irradiated with enhanced viability at lower concentration reduced higher concentration. low extract also cellular ROS generation increased anti-oxidant, glutathione. remarkable properties macrophages activated by agonist bacterial lipopolysaccharide (LPS). nitric oxide (NO) production suppressed expression genes. Conclusion: Together, these observations demonstrated potential role mediated both its on epithelial immune cells.